Biochemical Kinase Profiling and Screening

Kinase Screening & Profiling Service

We are offering a Panel of more than 300 validated protein kinase targets, including disease-relevant kinase mutants. All assays use human kinases made in-house and biologically relevant substrates.
Features of our profiling and screening assays:

  • Massive Kinome Coverage
  • Activity-Based Profiling & Screening
  • Confirm your results at higher ATP concentrations to identify potential Type II/III inhibitors
  • Build your own panel or consider our unique Pre-selected panels.
  • Our Mobility Shift Assay Platform measures kinase activity efficiently and effectively.

Our regular service assays at an ATP concentration of approximating Km. As a second option for a subset of kinases we can perform assays at 1 mM ATP and offer thereby:

  • Assessment of inhibitory potency and selectivity which may vary with the concentration of ATP available
  • Determination of mode of action of an inhibitor, i.e. distinguishing between type I and type II or III inhibitors
  • Approaching physiological ATP levels and providing insight to in vivo pharmacological behavior of an inhibitor
  • Possibility to screen for inhibitors that are non-competitive for the ATP binding site

Furthermore, we offer a Pre-incubation service suitable for certain classes of kinase inhibitors with slow binding kinetics. Kinase and test compound(s) are pre-incubated at room temperature for 30 minutes before the kinase reaction starts.

Lipid Kinase Screening & Profiling Service

For Lipid kinase screening and profiling we use the ADP-Glo™ assay platform.

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Privacy Policy

Kinase Logistics acknowledges the importance of proper protection and use of personal information we collect from you. Under the policies stated below, Kinase Logistics makes efforts to protect your personal information and make proper use of the information.

  1. Definitions of personal information
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Kinase Logistics
Data Controller
Skovvej 22
DK-6340 Krusaa